The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria Abstract The high recurrence rate of cystine lithiasis observed in cystinuria patients highlights the need for new therapeutic options to address this chronic disease. There is growing evidence of an antioxidant defect in cystinuria, which has led to test antioxidant molecules as new therapeutic [...]

New tiopronin delayed-release tablets launch with patient support for the treatment of cystinuria in the US Read Full Story BOSTON, May 13, 2024--(BUSINESS WIRE)--Cycle Pharmaceuticals Limited (Cycle) is pleased to announce the launch of tiopronin delayed-release tablets as a treatment option for patients with cystinuria.1 Tiopronin delayed-release tablets are available in 100 mg and 300 mg [...]

Kids and their battles with kidney stones Ivanhoe Newswire - Apr 28, 2024 - SEE ORIGINAL STORY When you think of kidney stones, you may think of middle-aged men. But that's changed dramatically over the last 20 years. More women are now experiencing them. 11% of Americans will have a kidney stone at some point. [...]

FDA grants orphan drug designation to ADV7103 for cystinuria Read Original Story Here The FDA has granted an orphan drug designation (ODD) to ADV7103 for the treatment of patients with cystinuria, according to a news release from Advicenne, the developer of the therapy.1 ADV7103 was also granted an ODD status by the FDA in [...]

Aeglea Cuts Majority of Staff Following Mixed Trial Results Published: Apr 12, 2023 - Original Story Wednesday, Aeglea Biotherapeutics announced it was reducing its headcount as part of a sweeping reorganization following mixed interim data from an ongoing Phase I/II study of its classical homocystinuria candidate pegtarviliase. As part of its strategic review, Aeglea is laying off all [...]

50 drugs at Mark Cuban's pharmacy with biggest cost reductions Original Story Here In 2023, Mark Cuban Cost Plus Drug Co. began selling two generic medications cheaper than their branded versions by more than $10,000. The two drugs are fingolimod hydrochloride, a multiple sclerosis medication, and penicillamine, which treats rheumatoid arthritis, metal toxicity and [...]

New funding will advance research into the treatment of rare kidney stone disease Dr Malcolm Starkey has received two grants to aid his group’s research on cystinuria, a rare kidney stone disease. Cystinuria, is a chronic condition, involving the formation of stones made from the amino acid cystine in the kidney. This disease is [...]

Cystinuria in Dogs: Symptoms, Causes, & Treatments Cystinuria in dogs is a medical condition that can cause kidney and bladder stones. The disorder is inherited, which means a dog is born with it. Technically, the condition is caused by a build up of the amino acid cystine in a dog’s urine. Usually, this [...]

Feds allege Keystone RV discriminated against worker with disabilityOriginal Story: Adam Yahya Rayes HEREFederal officials filed suit Wednesday against major northern Indiana RV manufacturer Keystone for alleged disability discrimination against an employee.The U.S. Equal Employment Opportunity Commission suit says an employee with a disability was fired for taking time off to attend his medical appointments [...]